Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) | PAR 25 109

Opportunity Information: Apply for PAR 25 109

The National Institutes of Health (NIH), through the NIH Common Fund, is offering the "Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)" under funding opportunity number PAR-25-109. The Kids First program was created to build and expand a high-value pediatric research data resource focused on the genetics of childhood cancers and structural birth defects. At its core is a growing collection of curated genomic sequence data paired with phenotypic (and, where relevant, clinical) information from multiple cohorts, made available through a central data portal that also provides tools for analysis. The overall purpose is to lower barriers to discovery by making well-characterized datasets broadly accessible, encouraging cross-cohort and cross-disease investigations that can improve diagnosis and ultimately inform more targeted therapies.

This specific opportunity supports small, meritorious research projects that primarily analyze existing Kids First genomic datasets and any associated phenotypic datasets housed within or linked to the Kids First Data Resource. Projects are expected to leverage these data to answer focused scientific questions about childhood cancer and/or structural birth defects, including work that compares patterns across cohorts, investigates genetic contributors to disease, or refines genotype-phenotype relationships. In addition to direct data analyses, the NOFO also allows proposals aimed at developing or adapting methods such as approaches, tools, pipelines, or algorithms that are well-suited for analyzing Kids First-relevant genomic, phenotypic, and clinical data. The emphasis is on research and analytics that extract new knowledge or enable better use of the Kids First resource, rather than generating new clinical trial activity (clinical trials are explicitly not allowed under this R03 announcement).

The funding mechanism is an NIH R03 small research grant, which is designed for narrowly scoped projects that can be completed with limited resources and within a shorter project horizon than larger NIH awards. The opportunity is categorized as discretionary and uses the grant funding instrument. The funding activity is listed under Education, Health, Income Security and Social Services, and the associated CFDA numbers include 93.121, 93.393, 93.399, and 93.865. While the notice does not list an award ceiling or expected number of awards in the provided excerpt, applicants should treat the R03 mechanism as supporting modest budgets and tightly defined aims centered on analysis of existing Kids First data.

Eligibility is broad and includes many types of U.S.-based organizations as well as certain non-U.S. entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other organizations. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This breadth is intended to encourage wide participation in pediatric genomics and birth defects research and to expand the community of investigators using the Kids First data resource.

Key dates in the provided source include a creation date of 2024-11-18 and an original closing date of 2025-11-16. Applications should be aligned with the central goal of using the Kids First Data Resource to produce meaningful, publishable insights or to deliver practical analytical methods that help the broader community interrogate pediatric cancer and structural birth defects datasets more effectively.

• The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.393, 93.399, 93.865.
• This funding opportunity was created on 2024-11-18.
• Applicants must submit their applications by 2025-11-16. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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