Opportunity Information: Apply for RFA AI 16 083

Revision Applications for U.S.-South Africa Program for Collaborative Biomedical Research (U01) is a National Institutes of Health (NIH) funding opportunity (RFA-AI-16-083) that supports expansion of already-funded work under the U.S.-South Africa Program for Collaborative Biomedical Research. It uses a cooperative agreement mechanism (U01), which typically means NIH staff will have substantial involvement in helping guide or coordinate the funded activities compared with a standard research grant. The overall aim is not to start entirely new, unrelated projects, but to provide additional support through revision applications so existing collaborations can broaden or strengthen specific program activities.

A central goal of this revision-focused FOA is to grow and diversify the pipeline of South African investigators who are actively engaged in collaborative research with U.S. partners. In particular, it emphasizes enhancing the pool of investigators in South Africa from backgrounds that are underrepresented in the country’s workforce. The intent is capacity-building through meaningful participation in research, strengthening career development and research leadership opportunities within ongoing U.S.-South Africa collaborations rather than treating diversity as a side objective. By tying the revisions to active collaborative projects, the FOA is designed to create practical, hands-on roles for these investigators within established research teams and infrastructure.

The scientific scope is focused on high-burden and high-priority health issues in South Africa that overlap strongly with NIH infectious disease and global health priorities. Supported areas include tuberculosis (TB); HIV/AIDS biomedical research; HIV/AIDS behavioral and social science research; and HIV-related co-morbidities, including malignancies (cancers linked to HIV infection and immunosuppression). In practice, that scope covers both the biological dimensions of infection and disease progression and the behavioral, social, and health-systems factors that influence prevention, treatment uptake, adherence, and outcomes. The mention of malignancies highlights attention to conditions such as HIV-associated cancers and other serious co-morbid diseases that complicate care and increase mortality.

Eligibility rules are specific and somewhat restrictive. The FOA indicates that non-U.S. entities (foreign institutions) are eligible to apply, and it also lists eligible applicants as public and state-controlled institutions of higher education. At the same time, it explicitly states that non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply, and that foreign components (as defined by the NIH Grants Policy Statement) are not allowed. The practical takeaway is that applicants must fit within the FOA’s eligibility structure without relying on a “foreign component” arrangement under a U.S. applicant organization, and they must align with NIH’s policy definitions. Because eligibility hinges on NIH policy terminology (for example, what counts as a foreign component versus a foreign institution applicant), the FOA’s full eligibility section would be the authoritative source for structuring the application correctly.

From an administrative standpoint, the opportunity is categorized as discretionary funding and falls under a broad activity category spanning education, health, and related social service areas, reflecting the capacity-building and workforce-development emphasis alongside biomedical research. The CFDA numbers associated with the opportunity are 93.393, 93.399, 93.855, 93.856, and 93.865, which correspond to different NIH program areas that can support aspects of infectious disease and related research and training activities. The FOA was created on December 8, 2016, and the original closing date was March 28, 2017. The excerpted listing does not provide a stated award ceiling or expected number of awards, so those details would normally need to be confirmed in the full FOA text or related NIH notices.

In plain terms, this FOA is about using revision applications to expand and strengthen existing U.S.-South Africa collaborative research efforts in TB, HIV, and HIV-related conditions, with a strong emphasis on bringing more underrepresented South African investigators into sustained, substantive research roles. It blends scientific priorities with workforce diversification and capacity development, within a cooperative agreement structure where NIH involvement is typically more hands-on than in standard grants.

  • The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Revision Applications for U.S.-South Africa Program for Collaborative Biomedical Research (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399, 93.855, 93.856, 93.865.
  • This funding opportunity was created on 2016-12-08.
  • Applicants must submit their applications by 2017-03-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Public and State controlled institutions of higher education.
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