Opportunity Information: Apply for RFA DK 20 507
This funding opportunity is a limited-competition NIH cooperative agreement (U24) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to continue the work of the Urinary Stone Disease Research Network (USDRN) Scientific Data Research Center. The USDRN is in the middle of running a multi-center randomized clinical trial along with an observational clinical study focused on urinary stone disease, and this announcement is designed specifically to support the completion of those ongoing clinical investigations rather than launching an entirely new network or a new set of unrelated studies. Because it is a U24 cooperative agreement and the title specifies "Clinical Trial Required," the funded center is expected to play an active, hands-on role in managing and executing clinical-trial-related scientific and operational responsibilities in close collaboration with NIH program staff, consistent with how cooperative agreements function (meaning NIH typically has substantial involvement compared with a standard research grant).
Scientifically, the work being supported centers on three connected goals. First, the network is testing whether increased fluid intake and higher urine output can reduce urinary stone disease recurrence, and it is not just looking at the biological theory but also at real-world adherence, using innovative strategies to help participants maintain higher fluid intake over time. Second, the network aims to better understand ureteral stent-associated pain and urinary symptoms and to develop or evaluate approaches that mitigate these burdens, which are common issues for patients who require stents. Third, the studies include structured collection of clinical data and biological samples intended to create a resource for future investigations, allowing additional research questions to be pursued later using well-characterized specimens and datasets.
Operationally, the announcement is about sustaining the Scientific Data Research Center function for USDRN so the ongoing randomized trial and observational study can be completed with strong data management, coordination, and scientific oversight. While the summary text does not list every task, a data research center in this context commonly provides centralized data coordination across sites, supports protocol and case report form implementation, ensures consistent data collection and quality control, oversees secure data systems, assists with monitoring and reporting, supports statistical and analytic activities, and helps manage study documentation and regulatory or compliance-related needs tied to multi-site clinical research. The emphasis on completing clinical investigations suggests continuity, stability, and the ability to carry forward existing systems, workflows, and institutional knowledge are central to what NIH is buying with this award.
Eligibility is restricted by design. The FOA invites applications from the current USDRN Scientific Data Research Center, making it a limited competition rather than an open call. The text also notes that certain other applicant types may be eligible (such as eligible federal agencies and U.S. territories or possessions), but foreign institutions cannot apply. In addition, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. In practical terms, this means the work must be led and carried out within allowable U.S.-based organizational structures, without foreign institutional applicants or foreign project components.
Key administrative details from the source listing include the Funding Opportunity Number RFA-DK-20-507, the activity mechanism U24 (cooperative agreement), the NIH as the agency, and an original closing date of February 9, 2021. The listing shows an award ceiling of $700,000. The opportunity is categorized under discretionary funding and is associated with CFDA number 93.847. Overall, the grant is best understood as targeted continuation support for the existing USDRN data coordinating infrastructure so NIDDK can finish generating high-quality evidence on fluid-intake interventions for stone recurrence, improve understanding and management of stent-related symptoms, and preserve data and biospecimens for future urinary stone disease research.Apply for RFA DK 20 507
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of the Urinary Stone Disease Research Network (USDRN) Scientific Data Research Center (U24 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2020-09-10.
- Applicants must submit their applications by 2021-02-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a limited-competition NIH cooperative agreement (U24) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to continue the work of the Urinary Stone Disease Research Network (USDRN) Scientific Data Research Center.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-20-507.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by NIDDK (National Institute of Diabetes and Digestive and Kidney Diseases), within NIH.
What is the activity mechanism and what does it mean?
The mechanism is U24, which is a cooperative agreement. In a cooperative agreement, NIH program staff typically have substantial involvement, and the funded center is expected to work closely with NIH in hands-on scientific and operational responsibilities rather than operating fully independently like a standard research grant.
Does this opportunity require a clinical trial?
Yes. The title specifies "Clinical Trial Required," and the center is expected to actively support and execute clinical-trial-related scientific and operational responsibilities tied to the ongoing USDRN clinical investigations.
Is this an open competition?
No. This is a limited competition. The FOA invites applications from the current USDRN Scientific Data Research Center rather than opening eligibility broadly.
What is the purpose of this award?
The purpose is to sustain and continue the USDRN Scientific Data Research Center so the ongoing multi-center randomized clinical trial and the observational clinical study can be completed with strong data management, coordination, and scientific oversight.
Is the award intended to launch a new research network or new unrelated studies?
No. The announcement is designed specifically to support completion of the ongoing USDRN clinical investigations rather than creating an entirely new network or starting a new set of unrelated studies.
What ongoing studies are being supported?
The USDRN is in the middle of running (1) a multi-center randomized clinical trial and (2) an observational clinical study focused on urinary stone disease, and this FOA is intended to support completion of those ongoing investigations.
What are the main scientific goals described for the USDRN work?
The supported work centers on three connected goals: (1) testing whether increased fluid intake and higher urine output reduce urinary stone disease recurrence while evaluating real-world adherence strategies; (2) improving understanding of ureteral stent-associated pain and urinary symptoms and developing or evaluating approaches to mitigate them; and (3) structured collection of clinical data and biological samples to create a resource for future research using well-characterized specimens and datasets.
What is the focus of the fluid-intake component of the research?
The network is testing whether increased fluid intake and higher urine output can reduce urinary stone disease recurrence, and it also focuses on adherence in real-world settings using innovative strategies to help participants maintain higher fluid intake over time.
What is being studied related to ureteral stents?
The network aims to better understand ureteral stent-associated pain and urinary symptoms and to develop or evaluate approaches that mitigate these burdens, which are common issues for patients who require stents.
Why are clinical data and biological samples being collected?
The studies include structured collection of clinical data and biological samples to create a resource for future investigations, enabling additional research questions to be pursued later using well-characterized specimens and datasets.
What role is the Scientific Data Research Center expected to play?
The Scientific Data Research Center is expected to provide centralized coordination and oversight that supports completion of the ongoing trial and observational study, including clinical-trial-related scientific and operational responsibilities in close collaboration with NIH program staff (consistent with the U24 cooperative agreement model).
What types of operational functions are typically included for a data research center in this context?
While not every task is listed in the summary, a data research center commonly provides centralized data coordination across sites; supports protocol and case report form implementation; ensures consistent data collection and quality control; oversees secure data systems; assists with monitoring and reporting; supports statistical and analytic activities; and helps manage study documentation and regulatory or compliance-related needs tied to multi-site clinical research.
Why does the FOA emphasize continuity and stability?
Because the goal is to complete ongoing clinical investigations, the emphasis suggests NIH values continuity, stability, and the ability to carry forward existing systems, workflows, and institutional knowledge for the USDRN Scientific Data Research Center.
Who is eligible to apply?
Eligibility is restricted. The FOA invites applications from the current USDRN Scientific Data Research Center. The text also notes that certain other applicant types may be eligible (such as eligible federal agencies and U.S. territories or possessions), but it is not an open call.
Are foreign institutions eligible to apply?
No. Foreign institutions cannot apply under this opportunity.
Are non-domestic components of U.S. organizations allowed?
No. Non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this award?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
Where must the work be led and carried out?
In practical terms, the work must be led and carried out within allowable U.S.-based organizational structures, without foreign institutional applicants or foreign project components.
What is the award ceiling listed for this opportunity?
The listing shows an award ceiling of $700,000.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.847.
What kind of funding category is this listed under?
The opportunity is categorized under discretionary funding.
What was the original closing date shown in the listing?
The original closing date shown is February 9, 2021.
How should this grant be understood overall?
This grant is best understood as targeted continuation support for the existing USDRN data coordinating infrastructure so NIDDK can complete the ongoing randomized trial and observational study, generate high-quality evidence on fluid-intake interventions for stone recurrence, improve understanding and management of stent-related symptoms, and preserve data and biospecimens for future urinary stone disease research.
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