Opportunity Information: Apply for PAR 21 316

The grant opportunity titled "Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)" (Funding Opportunity Number PAR-21-316) is a discretionary NIH grant led by the National Institutes of Health, aligned with NIMH priorities in mental health services research. It is a reissue of PAR-17-264 and is designed to fund R01-level research projects that do not include clinical trials. The central goal is to support innovative studies that generate practical knowledge about how to deliver high-quality mental health services in real-world settings, with an emphasis on approaches that can help the largest number of people, including individuals who currently have a mental illness and those at risk of developing one. The overall focus is on improving the delivery, quality, reach, and ongoing improvement of mental health services rather than testing clinical interventions in a trial format.

This announcement specifically targets mental health services research that can inform how systems, organizations, providers, and communities can improve the way care is delivered. In practice, that means projects are expected to connect to NIMH strategic priorities for services research and to emphasize service delivery questions such as access to care, quality improvement, implementation and sustainment of evidence-based practices in routine settings, service system organization and financing, workforce and service capacity, equity in service delivery, and strategies that improve outcomes at scale. Because the opportunity explicitly disallows clinical trials, applicants need to propose research designs that answer services-focused questions without assigning participants to intervention conditions in a way that meets the NIH definition of a clinical trial. Suitable projects may include observational studies, secondary data analyses, systems and policy evaluations, implementation research that does not involve a clinical trial design, methodological advances for services research, and other rigorous non-trial approaches aimed at improving mental health service delivery and continuous learning within service systems.

The funding mechanism is an R01 research project grant under the health activity category (CFDA 93.242). The opportunity is broadly open to a wide range of applicant organizations, reflecting the services research emphasis and the need to study care in diverse settings. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant types that are often central to community-based service delivery, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility is meant to encourage research that is embedded in the real service environments where people seek and receive mental health support.

Key administrative details included in the source information are that the opportunity was created on 2021-08-17, with an original closing date listed as 2023-01-06. The award ceiling and expected number of awards are not specified in the provided text, which typically means applicants would need to consult the full funding announcement and NIH policy guidance for budget expectations, project period norms, and any institute-specific constraints. Overall, the opportunity is best understood as an invitation to conduct rigorous, policy- and practice-relevant mental health services research at the R01 scale, focused on improving how mental health care is delivered and continuously improved in the settings where it actually happens, while staying clearly outside of clinical trial territory.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
  • This funding opportunity was created on 2021-08-17.
  • Applicants must submit their applications by 2023-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 21 316

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