Opportunity Information: Apply for PAR 19 059
Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21 Clinical Trials Optional) is an NIH grant opportunity designed to kick-start early-stage, locally grounded research on non-communicable diseases (NCDs) and injury in low- and middle-income countries (LMICs). It uses the R21 mechanism, which is typically geared toward exploratory work rather than large, fully powered studies. The emphasis is on planning, thoughtful study design, and small pilot efforts that can generate the preliminary evidence needed to launch stronger, longer-term research programs. Clinical trials are optional, meaning applicants can propose clinical trial activities if appropriate, but the program also supports non-trial research such as formative studies, feasibility testing, early implementation work, and methods development.
The scientific scope is broad and intentionally framed around real-world health needs across the lifespan, from childhood through older adulthood. Projects can focus on a single NCD or injury topic, but the announcement explicitly encourages research that cuts across multiple NCDs and shared risk factors. That includes work on overlapping drivers like tobacco use, unhealthy diet, physical inactivity, harmful alcohol use, air pollution, and social or structural determinants of health. Another highlighted priority is the intersection between NCDs and infectious diseases, including HIV/AIDS, such as studying NCDs as comorbidities, understanding how infectious disease treatment influences NCD risk, or developing integrated care approaches that address both infectious and chronic conditions in the same health systems and communities.
A central goal is to catalyze sustainable research capacity in LMIC settings. The expectation is that funded projects will do more than produce one-off findings; they should help establish a foundation for ongoing research programs led in partnership with LMIC institutions. In practice, that can mean building local skills, strengthening data systems, improving research governance or ethical review capacity, developing locally tailored measurement tools, and creating workflows that allow future studies to scale. The opportunity also signals interest in work that can ultimately contribute to better diagnostics, prevention strategies, treatment approaches, and implementation solutions that fit the realities of LMIC health systems. Beyond the immediate project, applicants are encouraged to think about how their work could support research networking and generate evidence that informs policy and program decisions.
Eligibility is structured around international collaboration and World Bank income classifications. Scientists based in the United States or in upper middle-income countries (UMICs) may partner with scientists at LMIC institutions, reflecting the program’s intent to combine complementary expertise while keeping the research locally relevant. Importantly, non-U.S. entities and foreign institutions are eligible to apply directly, which can help ensure that LMIC organizations can take leading roles. At the same time, non-U.S. components of U.S. organizations are not eligible to apply as the applicant organization, although foreign components (as NIH defines them in its Grants Policy Statement) are permitted within an application. The FOA points applicants to the World Bank country and lending group classifications for determining income category status.
From an administrative standpoint, this is a discretionary NIH grant (Funding Opportunity Number PAR 19 059) within health and environmental health-related activity categories, with CFDA numbers listed as 93.113, 93.213, 93.242, 93.307, 93.313, 93.321, and 93.867. The award ceiling is stated as $200,000, which reinforces the pilot and exploratory nature of the work: proposals should be ambitious in idea and potential impact, but realistic in what can be accomplished with limited funds and within an R21-style scope. The overall intent is to fund early, catalytic research that produces actionable learning, supports longer-term grant development, and strengthens LMIC-centered capacity to prevent and manage NCDs and injury over the long run.Apply for PAR 19 059
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21 Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.213, 93.242, 93.307, 93.313, 93.321, 93.867.
- This funding opportunity was created on 2018-11-07.
- Applicants must submit their applications by 2019-12-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This opportunity is the NIH Funding Opportunity Announcement (FOA) titled Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21 Clinical Trials Optional). It supports early-stage, locally grounded research on noncommunicable diseases (NCDs) and injury in low- and middle-income countries (LMICs) using the NIH R21 mechanism.
What is the FOA number?
The Funding Opportunity Number is PAR 19 059.
What type of grant mechanism is used?
The program uses the R21 mechanism, which is generally intended for exploratory or developmental research rather than large, fully powered studies.
What is the main purpose of the R21 approach in this program?
The emphasis is on planning and early evidence generation. Projects are expected to focus on thoughtful study design and small pilot efforts that can produce preliminary data or learning needed to support stronger, longer-term research programs.
Are clinical trials required?
No. Clinical trials are optional. Applicants may propose clinical trial activities if they fit the research aims, but the FOA also supports non-trial research.
If clinical trials are optional, what non-trial activities can be supported?
The FOA indicates support for work such as formative studies, feasibility testing, early implementation work, and methods development, alongside other exploratory research activities appropriate for an R21 scope.
What health topics are within scope?
The scientific scope is broad and covers noncommunicable diseases (NCDs) and injury across the lifespan, from childhood through older adulthood, with an emphasis on real-world health needs in LMIC settings.
Does the opportunity allow projects focused on a single NCD or injury topic?
Yes. Projects may focus on a single NCD or injury topic. At the same time, the announcement explicitly encourages research that cuts across multiple NCDs and shared risk factors.
What shared risk factors and drivers are highlighted?
The FOA highlights overlapping drivers and shared risk factors such as tobacco use, unhealthy diet, physical inactivity, harmful alcohol use, air pollution, and social or structural determinants of health.
Is the intersection of NCDs and infectious diseases part of the priority areas?
Yes. A highlighted priority is the intersection between NCDs and infectious diseases, including HIV/AIDS.
What kinds of NCD-infectious disease intersection research does this program encourage?
Examples described in the FOA include studying NCDs as comorbidities, examining how infectious disease treatment influences NCD risk, and developing integrated care approaches that address both infectious and chronic conditions within the same health systems and communities.
What does "across the lifespan" mean in this FOA?
It means the research can address health needs from childhood through older adulthood, rather than being limited to a single age group.
Is this grant focused on LMICs specifically?
Yes. The FOA is designed to support research that is locally grounded in low- and middle-income countries (LMICs).
How does the FOA define or determine LMIC status?
The FOA points applicants to World Bank country and lending group classifications to determine income category status.
Does the program involve international collaboration?
Yes. Eligibility and program intent emphasize international collaboration, combining complementary expertise while keeping the research locally relevant and grounded in LMIC institutions and contexts.
Who can partner on projects under this opportunity?
The FOA indicates that scientists based in the United States or in upper middle-income countries (UMICs) may partner with scientists at LMIC institutions.
Can non-U.S. entities apply directly as the applicant organization?
Yes. The FOA states that non-U.S. entities and foreign institutions are eligible to apply directly, which can enable LMIC organizations to take leading roles.
Can the non-U.S. component of a U.S. organization be the applicant organization?
No. The FOA specifies that non-U.S. components of U.S. organizations are not eligible to apply as the applicant organization.
Are foreign components allowed within an application?
Yes. The FOA notes that foreign components (as NIH defines them in its Grants Policy Statement) are permitted within an application.
What is the funding limit or award ceiling?
The FOA states an award ceiling of $200,000, reinforcing that proposed work should fit a pilot and exploratory R21-style scope.
What kinds of outcomes is NIH trying to catalyze with this FOA?
The FOA aims to catalyze early, actionable learning and produce preliminary evidence that can support longer-term grant development, stronger research programs, and improved LMIC-relevant solutions in areas like diagnostics, prevention, treatment approaches, and implementation strategies.
Is research capacity building in LMIC settings an expectation?
Yes. A central goal is to catalyze sustainable research capacity in LMIC settings. The FOA suggests that funded projects should help build foundations for ongoing research programs led in partnership with LMIC institutions.
What are examples of LMIC research capacity strengthening activities mentioned?
Examples include building local skills, strengthening data systems, improving research governance or ethical review capacity, developing locally tailored measurement tools, and creating workflows that allow future studies to scale.
Does the FOA emphasize policy or program relevance?
Yes. Beyond the immediate project, applicants are encouraged to think about how their work could support research networking and generate evidence that informs policy and program decisions.
What broad activity categories are associated with this opportunity?
The opportunity is described as a discretionary NIH grant within health and environmental health-related activity categories.
What CFDA numbers are listed for this opportunity?
The FOA lists CFDA numbers 93.113, 93.213, 93.242, 93.307, 93.313, 93.321, and 93.867.
What is the overall fit of a strong project concept for this FOA?
Based on the description provided, strong concepts are ambitious in idea and potential impact but realistic for limited funds and an exploratory timeline, clearly grounded in LMIC realities, and oriented toward generating the kind of early evidence and capacity that can lead to larger, longer-term research efforts.
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Applicants who have applied for this opportunity (PAR 19 059) also looked into and applied for these:
| Funding Opportunity |
|---|
| Bioengineering Research Partnerships (U01 Clinical Trial Not Allowed) Apply for PAR 19 156 Funding Number: PAR 19 156 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Innovative Approaches for Improving Environmental Health Literacy (R41/R42 Clinical Trial Not Allowed) Apply for RFA ES 19 006 Funding Number: RFA ES 19 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Innovative Approaches for Improving Environmental Health Literacy (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 005 Funding Number: RFA ES 19 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Award (K01 Independent Basic Experimental Studies with Humans Required) Apply for PAR 19 225 Funding Number: PAR 19 225 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 19 007 Funding Number: RFA ES 19 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Basic Experimental Studies with Humans Required) Apply for RFA ES 19 008 Funding Number: RFA ES 19 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed) Apply for PAR 19 249 Funding Number: PAR 19 249 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 009 Funding Number: RFA ES 19 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 19 010 Funding Number: RFA ES 19 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 19 004 Funding Number: RFA ES 19 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trial Not Allowed) Apply for RFA ES 19 003 Funding Number: RFA ES 19 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Pregnancy as a Vulnerable Time Period for Women's Health (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 003 Funding Number: RFA ES 20 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $300,000 |
| Limited Competition: Specialized Centers of Excellence on Environmental Health Disparities Research (P50) Apply for RFA MD 20 001 Funding Number: RFA MD 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01 Clinical Trial Not Allowed) Apply for PAR 19 386 Funding Number: PAR 19 386 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R21 Clinical Trial Not Allowed) Apply for PAR 19 385 Funding Number: PAR 19 385 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 005 Funding Number: RFA ES 20 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for RFA ES 20 002 Funding Number: RFA ES 20 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 20 006 Funding Number: RFA ES 20 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 20 009 Funding Number: RFA ES 20 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| U.S. - India Collaborative Environmental Health Research Program (R01 Clinical Trial Optional) Apply for RFA ES 20 010 Funding Number: RFA ES 20 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
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